It is increasingly recognized that environmental exposure to chemical, nutritional, and behavioral factors alters gene expression and affects health and disease by not only mutating promoter and coding regions of genes, but also by modifying the epigenome — modifications to DNA that confer an additional layer of heritable gene regulation that lead to disease when deregulated. The Dolinoy Environmental Epigenetics and Nutrition Lab investigates environmental epigenetics and gene-environment interactions using animal models, human clinical samples, and human population studies. Specifically, research focuses on nutrition and environmental chemicals and how many common compounds, such as bisphenol A (BPA), may have deleterious physiological consequences through abnormal epigenetic and genetic regulation. In 2013, the Dolinoy Lab was the first in the School of Public Health to be certified as Sustainable by Planet Blue at the University of Michigan. Primary improvements include the timely shutting of fume hood sashes, replacing the use of ethidium bromide with the safer alternative, Gel-Red, as well as conserving energy by turning off small equipment and computers.