The course will introduce classical, contemporary, and cutting-edge approaches to the estimation of human exposure to environmental and occupational agents as it relates to epidemiology studies as well as risk science, regulatory compliance, exposure source/route apportionment, and susceptibility factors. Qualitative and quantitative methods in exposure science will be covered, including surrogate measures, exposure modeling, and biological markers of exposure, in addition to statistical concepts such as exposure measurement error and efficient study design.