David Sherman

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Affiliations

The affiliations listed below show engagement with the Graham Sustainability Institute.

  • Water Center
    • Freshwater
      • U-M Large Grants
        • Grant Recipient
    • Event Participant

 

Hans W. Vahlteich Prof. Medicinal Chemistry
Assoc Dean for Res & Grad Educ
Prof of Medicinal Chem
Prof of Micro & Immun
Prof of Chem
Res Prof of Life Sciences
  • Literature, Science, & Arts
    • Chemistry
  • Medicine
  • Pharmacy
(734) 615-9907

Prof. Sherman received his B.A. in chemistry at UC Santa Cruz (1978) and Ph.D. in synthetic organic chemistry at Columbia University with Gilbert Stork (1981).  After working at Biogen Research Corporation, he moved to the John Innes Institute as a research scientist with Sir Prof. David A. Hopwood (1987-1990).  Following 13 years at the University of Minnesota, Prof. Sherman moved to the University of Michigan and is now the H. W. Vahlteich Professor of Medicinal Chemistry, Professor of Chemistry, and Professor of Microbiology & Immunology.  He is Research Professor in the Life Sciences Institute where his research laboratory pursues the discovery and analysis of diverse natural products and their biosynthetic pathways from bacteria and fungi.  Of particular interest is the genetic, biochemical and structural mechanisms involved in polyketide assembly and tailoring to produce complex secondary metabolites with potent biological activities against a range of targets, including cardiovascular, cancer and infectious diseases.  Current efforts include the isolation of new marine-derived bacteria and fungi from diverse habitats in Central America, the IndoPacific Region, the eastern Caribbean and the Red Sea.  The bulk of the laboratory’s pure culture collection is comprised of sediment derived shallow and deep-water actinomycetes and fungi.  More recently, metagenomic and metaproteomic technologies have been employed to identify, assemble and characterize natural product pathways from symbiont microbial consortia.  Heterologous expression and pathway engineering approaches are being developed to express these pathways for the discovery of new natural products.

In addition, Dr. Sherman is founding Director of the Center for Chemical Genomics at the University of Michigan Life Science Institute (LSI).  LSI maintains core facilities covering the areas of high throughput screening and drug discovery, structural biology and protein production with resources to support cross-disciplinary science including genetics; genomics and proteomics; molecular and cellular biology; and structural, chemical and computational biology.